Profil Klinis dan Laboratorium Pasien Anak dengan Infeksi Virus Dengue di Ruang Rawat Inap RSUD Sidikalang Periode September - Desember 2024
DOI:
https://doi.org/10.57213/medlab.v5i1.499Keywords:
Clinical Profile, Length of Stay, Pediatric Dengue, Thrombocytopenia, Warning SignsAbstract
Dengue virus infection continues to be a significant health issue in the Indonesian pediatric population, with a high risk of rapid progression to critical stages. Early identification of clinical and laboratory profiles is crucial for optimal management. This descriptive observational study aimed to determine the clinical and laboratory profiles of pediatric dengue patients hospitalized at Sidikalang Regional General Hospital from September to December 2024. A cross-sectional approach was used, analyzing retrospective medical records of pediatric patients aged 1–18 years diagnosed with dengue. Variables analyzed included age, gender, day of fever at admission, hospitalization length, warning signs, and hematological parameters, particularly platelet counts. The study included 24 patients, with equal gender distribution (50% male, 50% female). Most cases occurred in 7- and 8-year-olds (12.5% each). Patients typically arrived on the 3rd to 5th day of fever, with the peak on day 4 (37.5%). The average hospitalization was 4 days. Warning signs were present in 58.3% of patients and correlated with longer stays. At the beginning of treatment, 66.7% had thrombocytopenia, but by the end, 58.3% had normal platelets, showing hematological improvement. Early detection and continuous clinical and hematological monitoring are critical to prevent deterioration and optimize hospitalization duration.
References
Adam, A. S., Pasaribu, S., Wijaya, H., & Pasaribu, A. P. (2018). Warning sign as a predictor of dengue infection severity in children. Medical Journal of Indonesia, 27(2). https://doi.org/10.13181/mji.v27i2.2200
Adrizain, R., Husna, A. H., & Rezano, A. (2020). Correlation of thrombocytopenia and length of hospitalization in dengue child patient. Global Medical and Health Communication, 8(2). https://doi.org/10.29313/gmhc.v8i2.5506
CDC. (2025). Clinical features of dengue. Centers for Disease Control and Prevention. https://www.cdc.gov/dengue/hcp/clinical-signs/index.html
Dash, M. K., Samal, S., Rout, S., Bhola, R. K., Gartia, J., Saha, I., Behera, C. K., Hamdi, H., & Sahu, M. C. (2025). Association of intermediate monocytes with dengue severity among the pediatric population of Odisha, India. Scientific Reports, 1-14. https://doi.org/10.1038/s41598-025-21089-0
Fasitasari, M., Pertiwi, D., Wibowo, J. W., Indrayani, U. D., & Athatsaniya, M. D. (2024). Hubungan status gizi dengan derajat trombositopenia pada anak dengan demam berdarah dengue: Studi observasional analitik di RSI Sultan Agung Semarang. Journal of Holistics and Health Sciences, 6(1), 40-48. https://doi.org/10.35473/jhhs.v6i1.399
Fuadah, N. T., Sarinengsih, Y., & Helena, D. F. (2024). Profile of dengue hemorrhagic fever cases in children. Journal of Language and Health, 5(3), 1545-1550. https://jurnal.globalhealthsciencegroup.com/index.php/JLH/article/view/5272
Guo, L., Gu, Y., Zhang, Y., Zhang, H., Weng, W., & Wu, S. (2025). Platelet dynamics and thrombocytopenia in dengue fever: A prospective cohort study from Shenzhen, China. New Microbes and New Infections. https://doi.org/10.1016/j.nmni.2025.101624
Hanifah. (2025). Children more vulnerable to dengue, UGM professor highlights symptoms to watch for. Universitas Gadjah Mada. https://ugm.ac.id/en/news/children-more-vulnerable-to-dengue-ugm-professor-highlights-symptoms-to-watch-for/
Hossain, J., Das, M., Shahjahan, M., & Islam, W. (2025). Clinical and hematological manifestation of dengue patients in 2022 outbreak: A tertiary care hospital-based cross-sectional study. Health Science Reports, 8(1). https://doi.org/10.1002/hsr2.70356
Islam, S., Saeed, A., Id, K., & Badal, F. A. (2022). Clinical and hematological profiles of children with dengue residing in a non-endemic zone of Bangladesh. PLOS Neglected Tropical Diseases, 1-11. https://doi.org/10.1371/journal.pntd.0010847
Karyanti, M. R., Uiterwaal, C. S. P. M., Hadinegoro, S. R., Widyahening, I. S., Saldi, S. R. F., Heesterbeek, H., Hoes, A. W., & Bruijning-Verhagen, P. (2024). The value of warning signs from the WHO 2009 dengue classification in detecting severe dengue in children. The Pediatric Infectious Disease Journal, 43(7), 630-634. https://doi.org/10.1097/INF.0000000000004326
Kusuma, S. S. (2025). Clinical manifestations and complications of dengue infection in children: Insights and comparisons with adult cases. Clinical Diagnosis and Knowledge, 52(1), 6-9. https://doi.org/10.55175/cdk.v52i8.1518
Maharani, N. D., Wijaya, I., Garmana, G., Zhafira, A. F., Hafiza, A. G., Tiara, L., M, A. F., Azkia, S. N., Fathia, N. R., Sehan, P. N., Subekti, R. O., Hadi, R. H., & Hidayat, Y. (2025). Comparison of dengue hemorrhagic fever (DHF) cases between male and female in Bandung city. International Journal of Quantitative Research and Modeling, 6(3), 354-363. https://doi.org/10.46336/ijqrm.v6i3.1038
Mar, K., Cardona, S., Nelly, B., Jaramillo, R., Emilio, J., Fl, S., Esther, Y., Ortega, D., Stella, L., Cardona, G., & Naranjo, M. A. (2024). Clinical manifestations of dengue in children and adults in a hyperendemic region of Colombia. The American Journal of Tropical Medicine and Hygiene, 110(5), 971-978. https://doi.org/10.4269/ajtmh.23-0717
Maryam, H. A., Rais, H., Anwer, T., Safdar, S., & Bai, P. (2025). Clinical spectrum of dengue fever among children: A hospital-based study. The Professional Medical Journal, 32(03), 315-321. https://doi.org/10.29309/TPMJ/2025.32.03.8840
Mishra, S., Ambey, R., Khare, A., & Gaur, A. (2025). Clinico-epidemiological profile of dengue in children of age group 0-14 years admitted in a tertiary care hospital. CUREUS, 17(6). https://doi.org/10.7759/cureus.87027
Panchanadikar, N. T., Palkar, S. H., & Lalwani, S. K. (2025). Outcome of dengue infection and risk factors for severe dengue in Indian children. Journal of Vector Borne Disease, 62(3), 344-350. https://doi.org/10.4103/jvbd.jvbd_43_24
Pangestika, N. P. W., Gustawan, I. W., & Utama, I. M. G. D. L. (2022). Karakteristik anak dengan infeksi dengue di RSUP Sanglah, Denpasar, Bali. Intisari Sains Medis, 13(1), 232-237. https://doi.org/10.15562/ism.v13i1.1261
Putri, W. I., Ramaningrum, G., Ratnaningrum, K., & Prihandani, O. R. (2025). Analisis faktor risiko terjadinya dengue shock syndrome (DSS) pada pasien DBD anak. Jurnal Kesehatan Tambusai, 6(2), 6493-6499. https://doi.org/10.31004/jkt.v6i2.42746
Recker, M., Fleischmann, W. A., Nghia, T. H., Truong, N. Van, Nam, L. Van, Anh, D. D., Song, L. H., The, N. T., Anh, C. X., Hoang, N. V., Truong, N. M., Toan, N. L., Kremsner, P. G., & Velavan, T. P. (2024). Markers of prolonged hospitalization in severe dengue. PLOS Neglected Tropical Disease, 18(1), 1-16. https://doi.org/10.1371/journal.pntd.0011922
Salsabiela, S., Puspitasari, M., & Jatmiko, S. W. (2023). Blood parameters and length of hospitalization in pediatric dengue virus infection patients. International Summit on Science Technology and Humanity, 2022, 1339-1345. https://doi.org/10.23917/iseth.5539
Sarira, A., Kaunang, W. P. J., & Ratag, B. T. (2025). Hubungan antara usia, jenis kelamin dan jumlah trombosit dengan kejadian demam berdarah dengue pada pasien di Rumah Sakit Umum GMIM Pancaran Kasih Manado. Jurnal Pengabdian Ilmu Kesehatan, 5(2).
Setyaningrum, T. A., & Saputra, O. (2025). Demam berdarah dengue dengan warning sign pada anak perempuan 7 tahun dengan gizi kurang: Laporan kasus. Jurnal Kedokteran Universitas Lampung, 9(2), 238-242. https://juke.kedokteran.unila.ac.id/index.php/JK/article/view/3721
Susanto, N., Izhar, M. D., & Manangsang, F. (2025). Children under 5 years as predicting dengue transmission in Kebumen District, Indonesia: Case study mapping approaches. Journal of Epidemiology and Public Health, 10, 295-307. https://doi.org/10.26911/jepublichealth.2025.10.03.02
Tao, L., Zou, Y., Liu, T., Tan, G., Sun, L., Liu, X., & Wang, W. (2025). Trends in burdens of dengue fever among children aged 0-14 years in China from 1990 to 2021: Findings from the Global Burden of Disease Study 2021, and projections up to 2035. Global Health Journal, 9(2), 145-152. https://doi.org/10.1016/j.glohj.2025.06.010
WHO. (2022). National guideline for clinical management of dengue 2022. WHO Timor-Leste. https://share.google/rvuOUXydZbjQxxbTi
WHO. (2023). Dengue - Global situation. World Health Organization. https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON498
WHO. (2024). Dengue - Global situation. World Health Organization. https://www.who.int/emergencies/disease-outbreak-news/item/2024-DON518
WHO. (2025). Dengue. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue
WHO. (2026). Dengue and severe dengue fact sheet. World Health Organization. https://www.who.int/indonesia/id/emergencies/dengue-and-severe-dengue-fact-sheet
Zhang, W., Zhao, T., Wang, C., He, Y., & Lu, H. (2025). Assessing the global dengue burden: Incidence, mortality, and disability trends over three decades. PLOS Neglected Tropical Disease, 1-18. https://doi.org/10.1371/journal.pntd.0012932
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Jurnal Medical Laboratory
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
